Nitroglycerin ®
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Reviewed on May 07, 2026. by Dr Alexandra Cristina Cowell Writer & Clinical Content Reviewer Next review due on May 07, 2029.
Dr Alexandra Cristina Cowell

Last updated on May 07, 2026.

Angina medication you place under your tongue.

Nitroglycerin is a pill for angina. It dissolves in your mouth, and you can put it under your tongue, or between your gum and inner cheek. It works by widening your blood vessels to relieve your angina symptoms. And because the pills bypass your digestive system, they’re absorbed directly into your blood stream.

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$92.95
  • Prices include:
    Express shipping

    2-5 day shipping by secure courier

  • Consultation + Access to our clinicians

    Ask our experts anything you like, any time you want.

  • Total
    $92.95
    Save $0.00 each order
Nitroglycerin Nitroglycerin

What is Nitroglycerin?

Nitroglycerin is a type of nitrate medication that helps widen and relax blood vessels. And because it’s absorbed into your bloodstream quickly, it can relieve angina attacks as they start.

The pills are sublingual, which means they work without being digested the way most other oral meds do. You place them under your tongue or inside your cheek, allowing them to dissolve and the medication to start working immediately.

How does Nitroglycerin work?

Nitrates like Nitroglycerin are vasodilators.[1] These work by relaxing smooth muscle, decreasing your heart’s workrate and helping blood flow around your body more easily.

Angina causes arteries to narrow. By relaxing these arteries and increasing blood flow to your heart, Nitroglycerin can relieve angina symptoms such as chest pain, tightness, and heaviness.

The tablets can be taken at the onset of symptoms, and usually start working within minutes of taking them.

What doses of Nitroglycerin are there?

Nitroglycerin is available in three strengths: 0.3mg, 0.4mg, 0.6mg.

Your physician can help you choose the right dose based on your symptoms. It might be a case of starting you on the lowest one first to see if that works for you. If it doesn’t, they can discuss moving you up to a higher dose.

How long does Nitroglycerin take to work?

Sublingual Nitroglycerin pills usually start to work within 1-3 minutes of taking them, with the maximum effects typically felt after five minutes.

Treated trusted source:

  1. Kim, K.H., et al (2023). Nitroglycerin. PubMed.
Dr Alexandra Cristina Cowell 23938
This page was medically reviewed by Dr Alexandra Cristina Cowell on May 07, 2026. Next review due on May 07, 2029.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Nitroglycerin Nitroglycerin

How to use Nitroglycerin

Take your pill at the onset of angina symptoms, such as chest tightness, pain or pressure.

Place it underneath your tongue, or on the inside of your cheek, and allow it to dissolve completely. Avoid biting or chewing it.

If you need to, you can take another pill every five minutes, with the maximum dose being three pills a day.

If you feel like this isn’t working well enough to relieve your angina, speak to your doctor about increasing your dose.

Dr Alexandra Cristina Cowell 23938
This page was medically reviewed by Dr Alexandra Cristina Cowell on May 07, 2026. Next review due on May 07, 2029.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Nitroglycerin Nitroglycerin

Nitroglycerin isn’t suitable for everyone, and there are some things to be aware of when using it.

Here’s all the official info about your medication. If anything is unclear, let your physician know and they can talk with you about it.

 

Nitroglycerin Nitroglycerin

Nitroglycerin: FAQ

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

Is Nitroglycerin similar to other angina meds?

Answer:
Nitroglycerin is considered a first-line medication for relieving angina symptoms.

Isosorbide mononitrate or dinitrate is another type of nitrate which works in a similar way, and like Nitroglycerin, it can be taken sublingually. Isosorbide is also sometimes prescribed as a pill you take daily to prevent angina attacks, rather than relieving acute (short-term) episodes as they start.

Other types of medications used for long-term angina management include beta-blockers, which slow down your heart rate, and statins, which can prevent plaque from building up in your arteries (often used for high cholesterol).

Do I need a prescription for Nitroglycerin?

Answer:
You’ll need a prescription to start using Nitroglycerin. This is so a physician can check it’s the safest, most suitable option for relieving your angina symptoms.

And if you’re taking any other medications to manage your angina, such as beta-blockers, they’ll want to check that these won’t interact with Nitroglycerin in a harmful way.

Will Nitroglycerin cure my angina?

Answer:
Sublingual Nitroglycerin pills are used to relieve, rather than cure, angina symptoms.

Rather than being a condition in and of itself, angina tends to be a symptom of other underlying heart conditions, such as coronary artery disease.[1] This causes plaque to build up in your arteries, and reduces blood flow to your heart.

So taking Nitroglycerin won’t treat the underlying cause of your symptoms, but it can help to relieve them when they happen and prevent them going forward.

Will Nitroglycerin cause side effects?

Answer:
All medications have the potential to cause side effects, but not everyone will be affected by them.

The package insert that comes with your pills lists all the side effects you might get. If any side effects you get are serious, such as difficulty breathing or swallowing,[2] seek urgent medical attention at your nearest hospital’s emergency department.

Can I get Nitroglycerin through private health insurance?

Answer:
Medications that are covered by health insurance can vary widely, as it can depend on factors like the type of plan you have and where you’re getting your treatments from.

With this in mind, it’s always worth checking with your provider so you know exactly what is covered in your plan. If Nitroglycerin isn’t included, you’ll have to source it independently from an online pharmacy and pay for it out of pocket.

Treated trusted source:

  1. National Heart, Lung and Blood Institute (2022). Angina (Chest Pain) – Causes and Risk Factors.
  2. MedlinePlus (2024). Nitroglycerin sublingual: MedlinePlus drug information. medlineplus.gov.

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