Imiquimod
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Reviewed on Apr 24, 2026. by Dr Alexandra Cristina Cowell Writer & Clinical Content Reviewer Next review due on April 20, 2029.
Dr Alexandra Cristina Cowell

Last updated on Apr 24, 2026.

Helps clear abnormal verruca cells.

Imiquimod works by stimulating your immune system to destroy abnormal cells. It comes in a 5% solution and is applied five times a week for up to six weeks.

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Imiquimod Imiquimod

What is Imiquimod?

Imiquimod helps treat infections, such as warts, by destroying diseased cells. It does this by stimulating your immune system to track damaged cells. Plantar warts are commonly caused by the human papillomavirus (HPV), which produces proteins on the outer layer of your skin, usually on your feet.[1]

While warts can go away without treatment, it can take around two years for them to fully heal. Using Imiquimod can help speed up this process and treat them within a few weeks.

Imiquimod is an off-label treatment for warts, meaning it’s not officially licensed to treat them. This doesn’t mean it’s not safe; off-label prescribing is a common practice that can be done when your doctor thinks a certain medication will be safe and suitable for you.

How does Imiquimod work?

Imiquimod helps your immune system find and get rid of bad cells. It does this by tracking cells that are infected or damaged, and supporting the release of molecules like cytokines that help signal your immune system to destroy them. Essentially, it helps your immune system clear infections more effectively.[1]

How long does Imiquimod take to work?

Imiquimod is absorbed slowly through your skin, sometimes taking a few hours to be completely absorbed. It’s important that you don’t get your feet wet during this time to avoid the cream being washed away.

Plantar warts can take a long time to heal, so it might take a while before you see the results.

The treatment is initially prescribed for six weeks, so by this time, your verruca should have gone. But if it persists, let your doctor know – they might keep you on the treatment for longer.

What doses of Imiquimod are there?

Imiquimod only comes in a concentration of 5%. You’ll typically apply a thin layer once a day.

Treated trusted source:

  1. Nanda, J. and Bermudez, R. (2023). Imiquimod. PubMed.
Dr Alexandra Cristina Cowell 23938
This page was medically reviewed by Dr Alexandra Cristina Cowell on April 20, 2026. Next review due on April 20, 2029.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Imiquimod Imiquimod

How to use Imiquimod

Apply the cream five days a week for up to six weeks – you can choose any five days you want to apply it.

To use Imiquimod:

  • Apply Imiquimod at bedtime
  • Wash your hands
  • Wash the affected area with mild soap and water
  • Open the sachet
  • Squeeze some cream onto your fingers
  • Apply a thin layer to the affected area
  • Gently rub it in
  • Throw away the sachet, even if there’s cream left inside
  • After 6 to 10 hours, wash the affected area with soap and water again

Open a new sachet each time you use Imiquimod. Avoid getting the area wet after application.

Dr Alexandra Cristina Cowell 23938
This page was medically reviewed by Dr Alexandra Cristina Cowell on April 20, 2026. Next review due on April 20, 2029.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Imiquimod Imiquimod

Hydrocortisone isn’t suitable for everyone, and there are some things that you need to be aware of when taking it.

Here’s all the official info on it. If anything is unclear, let our doctor know, and they can talk with you about it.

Imiquimod Imiquimod

Imiquimod: FAQ

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

How well does Imiquimod work for plantar warts?

Answer:
Imiquimod is an effective treatment for warts (also known as plantar warts). In one study, patients using Imiquimod three days a week were fully treated within a few weeks. The study noted that it was a safe and efficient treatment with high patient satisfaction.[1]

Similar results were found in another study that used Imiquimod and duct tape. Most of the patients using this treatment were fully or partially healed, while only a few patients had no response to the treatment.[2]

Is Imiquimod available without a prescription?

Answer:
No, you can only get Imiquimod with a prescription. This way, your doctor can check if it's safe and suitable for you. They’ll also monitor your treatment progress and make sure everything is fine.

Will I get side effects from Imiquimod?

Answer:
Yes, you might get side effects when taking Imiquimod, although not everyone will get them. The side effects may include:

  • Thinning of the skin

  • Redness

  • Flakiness

  • Swelling

  • Burning sensation


The side effects are usually mild and should subside once you stop treatment. Any skin reaction caused by Imiquimod should resolve within two weeks of stopping treatment. If you have any concerns, let your doctor know.

Can I get Imiquimod through private health insurance?

Answer:
This depends on your private insurance plan. Certain insurers only cover specific brands, but it’s always best to ask your provider whether they cover your preferred treatment.

If it isn’t covered, you can always get Imiquimod from an online service, but this will be at your own expense.

Treated trusted source:

  1. López-Giménez, M.T. (2013). Five Cases of Recalcitrant Plantar Warts Successfully Treated with Imiquimod 5% Cream. Actas Dermo-Sifiliográficas (English Edition), 104(7), pp.640–642.
  2. Kim, S. Y., et al. (2013). New Alternative Combination Therapy for Recalcitrant Common Warts: The Efficacy of Imiquimod 5% Cream and Duct Tape Combination Therapy. Annals of Dermatology, 25(2), 261.

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