Betamethasone Dipropionate Cream
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Reviewed on Jul 6, 2026. by Dr Alexandra Cristina Cowell Writer & Clinical Content Reviewer Registered with GPhC (No. 2241935) Next review due on July 02, 2029.
Dr Alexandra Cristina Cowell

Last updated on Jul 06, 2026.

Stops inflammation in skin cells to relieve psoriasis symptoms.

Betamethasone Dipropionate is an FDA-approved cream that can help relieve psoriasis symptoms. It’s a potent corticosteroid, meaning it’s stronger than over-the-counter options like Hydrocortisone, but not as strong as the most potent options like Clobetasol.

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0.05% cream
$99.95
  • Prices include:
    Express shipping

    2-5 day shipping by secure courier

  • Consultation + Access to our clinicians

    Ask our experts anything you like, any time you want.

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Betamethasone Dipropionate Cream Betamethasone Dipropionate

What is Betamethasone Dipropionate Cream?

Betamethasone is a potent corticosteroid cream that can help ease symptoms of psoriasis. You’ll usually apply a small amount of Betamethasone Dipropionate Cream once or twice a day to help manage psoriasis.

How does Betamethasone Dipropionate Cream work?

Betamethasone Dipropionate has an antiproliferative effect on skin cells, which means it slows down the rapid growth and multiplication of these cells.[1] Psoriasis is caused by the rapid turnover of skin cells, which leads to thick, inflamed patches of skin.. By slowing this process down, it helps relieve symptoms of psoriasis.

Psoriasis can also cause your skin to become inflamed, irritated, and red. Betamethasone Dipropionate can help reduce swelling and irritation by narrowing blood vessels near your skin’s surface, which means less of the substances in your body responsible for inflammation reach your skin.[2]

It can also mimic the action of your body’s natural anti-inflammatory hormone (known as cortisol), blocking the production of these inflammatory substances.[2] And it can also ‘switch off’ genes responsible for inflammation that are activated by psoriasis.[3] These effects should help to ease swelling, redness, and itching caused by psoriasis.

How do Betamethasone Dipropionate doses work?

Betamethasone Dipropionate Cream comes in one dose for psoriasis, which is a 0.05% w/w cream. 0.05% w/w means that every gram of treatment is made up of 0.05% active ingredient (0.5 mg).

What is the active ingredient in Betamethasone Dipropionate Cream?

Betamethasone Dipropionate cream isn’t a branded treatment, it’s a generic. This means it’s designed to be very similar to an already marketed brand-name drug, but without the price tag that comes along with the branding.

Betamethasone Dipropionate gets its name from its active ingredient, betamethasone dipropionate. It’s a potent topical corticosteroid that can help relieve inflammation and irritation, as well as reduce the rapid multiplication of skin cells characterizing psoriasis.

Treated trusted source:

  1. Guichard, A. et al. (2014). Effects of topical corticosteroids on cell proliferation, cell cycle progression and apoptosis: in vitro comparison on HaCaT. Comparative Study. 429(2). pp. 422-429.
  2. Gabros, S. et al. (2025). Topical Corticosteroids. StatPearls. Treasure Island (FL): StatPearls Publishing.
  3. Barnes, P.J. (2006). How corticosteroids control inflammation: Quintiles Prize Lecture 2005. British Journal of Pharmacology. 148(3). pp. 245-254.
Dr Alexandra Cristina Cowell 23938
This page was medically reviewed by Dr Alexandra Cristina Cowell on July 02, 2026. Next review due on July 02, 2029.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Betamethasone Dipropionate Cream Betamethasone Dipropionate

How to use Betamethasone Dipropionate Cream

Always use Betamethasone Cream exactly as you’ve been instructed by your prescriber.

You’ll usually apply a thin layer of cream over the affected area. Typically, you’ll apply it once or twice a day over a period of two to three weeks. But this could be longer depending on the severity of your psoriasis and your prescriber’s guidance.

Dr Alexandra Cristina Cowell 23938
This page was medically reviewed by Dr Alexandra Cristina Cowell on July 02, 2026. Next review due on July 02, 2029.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Betamethasone Dipropionate Cream Betamethasone Dipropionate

Betamethasone Dipropionate isn’t suitable for everyone, and there are some things that you need to be aware of when taking it.

Here’s all the official info on it. If anything is unclear, let our clinician know, and they can talk with you about it.

Betamethasone Dipropionate Cream Betamethasone Dipropionate

Betamethasone Dipropionate Cream: FAQ

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

Are there any alternatives to Betamethasone Dipropionate Cream?

Answer:
There are a few different options available to manage psoriasis. If Betamethasone Dipropionate hasn’t been as effective as you’d hoped, a more potent corticosteroid like Clobetasol Propionate could be a more suitable option. If corticosteroids aren’t the right treatment for you, alternatives like Otezla or Tazarotene might be a better fit.

Otezla is a type of PDE4 inhibitor that helps manage inflammatory action within cells. It comes as a pill that works inside your body, so it could be a good option if you’d prefer not to apply cream, too. It works by regulating inflammation inside cells to reduce redness and scaling caused by psoriasis.[1]

Tazarotene is a type of retinoid that slows down the overproduction of skin cells that characterizes psoriasis. This should help soften the buildup of plaque, reduce scaling, and ease inflammation.[2]

How effective is Betamethasone Dipropionate Cream for psoriasis?

Answer:
Betamethasone has proven to be an effective treatment for managing psoriasis in clinical trials. In one study of 62 individuals with psoriasis, 57% of participants using Betamethasone Dipropionate twice a day for three weeks reported being ‘much better’ in the overall assessment at the end of the trial.[3] The patients experienced a reduction in inflammation, scaling, itching and pain.

Do I need a prescription for Betamethasone Dipropionate Cream?

Answer:
Yes. Betamethasone is a strong topical corticosteroid, so a healthcare professional will need to check that it’s a safe and suitable treatment for you before you can use it. You may also need to check in with your doctor regularly while using it, as it can cause side effects like thin skinning if it’s used too much.

What should I do if I make a mistake when using Betamethasone Dipropionate Cream?

Answer:
If you’ve forgotten to use Betamethasone Dipropionate, just use it as soon as you remember, and then carry on with your next scheduled dose as normal. If you’ve applied Betamethasone Dipropionate more often than you should, or applied too much cream, speak to your doctor or pharmacist as it could affect some of your hormones.

Can Betamethasone Dipropionate Cream cause side effects?

Answer:
Usually, when Betamethasone Cream is used correctly, it doesn’t cause any problems. But if you apply more cream than you should, especially on your face, it may cause:

  • Redness

  • Stinging

  • Blistering

  • Peeling

  • Swelling

  • Itching

  • Burning

  • Skin rash

  • Dryness

  • Inflammation of hair follicles

  • Excessive hair growth

  • Reduced skin pigmentation

  • Allergic reactions

  • Skin inflammation or infections

  • Skin thinning

  • Red marks

  • Blurred vision

Can I get Betamethasone Dipropionate Cream through private health insurance?

Answer:
This depends on your health insurance plan.. Check the formulary of your health plan (the list of approved drugs they cover) to see whether your insurance provider covers Betamethasone Dipropionate.

You may also need prior authorization before your insurance provider will cover it, which means your doctor will be asked to prove that Betamethasone Dipropionate is a medical necessity for your psoriasis.

Your insurance provider may only cover part of the cost of Betamethasone Dipropionate, and may only offer coverage if it’s obtained through certain healthcare providers. But if Betamethasone Dipropionate isn’t available through your health plan, you should still be able to get it through an online pharmacy service (if it’s a suitable treatment for you).

Treated trusted source:

  1. National Psoriasis Foundation. (n.d). Otezla (apremilast).
  2. American Academy of Dermatology Association. (n.d). Psoriasis treatment: A retinoid you apply to the skin. AAD.
  3. Afzelius, H.W. Jacobsen, K.U. (1979). A double-blind controlled trial of betamethasone dipropionate 0.05% (Diproderm) in comparison with fluocinolone acetonide 0.025% (Synalar) in psoriasis and other steroid-responsive dermatoses. Journal of International Medical Research. 7(5). pp. 411-414.

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