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Pramipexole is a generic treatment for restless legs syndrome, it belongs to a family of medicines known as dopamine agonists. These work by stimulating the dopamine receptors in the brain. In turn, this can trigger the nerve impulses that help control body movement.

If you want to order Pramipexole, you can do so using our secure online pharmacy. Simply take our questionnaire to have you symptoms assessed by a member of our qualified medical team. We dispense from our UK pharmacy, using a third party courier.

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This content was reviewed by a clinician on

12 November 2020
dr daniel

Dr Daniel Atkinson

(GP Clinical Lead - GMC No. 4624794) 12 November 2020
Product information

Pramipexole is a treatment for restless legs syndrome. It is the generic version branded counterpart Mirapexin, manufactured by Boehringer Ingelheim. Pramipexole belongs to a family of medications called dopamine receptor agonists. It is typically used initially in low doses, and increased incrementally until a maintenance dose is found. That is, a dose which best controls and alleviates the symptoms of restless legs syndrome. 

Restless legs syndrome is a relatively common condition which affects the central nervous system. It causes an inability to resist moving the legs, and in rarer cases the arms. It can also bring about an unpleasant ‘crawling’ sensation in the feet, calves or ankles. The symptoms of restless legs syndrome typically become worse at night. The condition is associated with periodic limb movements in sleep (PLMS), of which involuntary convulsions or movements in the legs or arms become present at night or in sleep. 

For some, restless legs syndrome affects them only occasionally whereas others feel symptoms every day. The symptoms can also range from moderate to severe. Severe symptoms can greatly disrupt a person’s daily routine and overall quality of life. 

There isn’t always an obvious cause for restless legs syndrome, known as idiopathic or primary restless legs syndrome. It can be inherited from parents or other family members. It is thought by some that the condition stems from how the body deals with a particular neurotransmitter, a hormone, called dopamine. Dopamine has several functions, one of which surrounds the muscles and movement. Some argue that dopamine may be the cause of restless legs syndrome. 

However, in some cases, other causes may be present - this may include underlying health conditions, such as iron deficiency or kidney failure. There may also be a connection between the condition and women who are pregnant. Around 20% of women will experience symptoms of restless legs syndrome in their third trimester, though the condition typically stops being observed following birth. 

Medical professionals may recommend a number of treatments for restless legs syndrome, including adopting, where possible, a good sleep routine, quitting smoking and exercising regularly. Where natural treatment methods do not help symptoms, medicinal treatment may be prescribed. If iron deficiency is thought to be the cause, a course of iron supplements may help. 

Other medicinal treatments include those which help to increase the levels of dopamine the body produces, such as Pramipexole. When Pramipexole is taken, it stimulates the dopamine receptors in the brain. This helps to restore dopamine signalling in the brain which can help to control the symptoms of restless legs syndrome. Speak with your doctor or pharmacist if you’re taking Pramipexole and your symptoms do not improve. You should also not take this treatment for a longer period than 12 months. 

Take our questionnaire to have your symptoms evaluated by one of our qualified clinicians. Prescriptions may also be issued pending approval. We dispense all orders at our UK pharmacy, and ship using a third-party courier. Order before 4pm Monday to Friday, and receive your treatment the following day.

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Page last reviewed:  12/11/2020

It’s important you always take medication exactly as it has been prescribed. If you’re unsure, you can read the patient information leaflet included with each packet. 

  1. Take as directed. 
  2. Typically, you will be instructed to take one tablet, with water, two to three hours before you sleep in the evening. 
  3. Your treatment will commence with a starting dose, often the lowest dose available, and is usually increased after one week. 
  4. Your medication dosage may be increased incrementally until a maintenance dose is found, which helps to best control your symptoms. 
  5. You must keep taking Pramipexole until you are instructed otherwise by your doctor or prescriber. 
  6. The sudden cessation of treatment can cause side effects. If you want to stop taking this medication, you’ll be instructed to decrease your dosage over a period of time. 

Speak to your doctor or pharmacist if you have any questions about how to take this medication.

Page last reviewed:  12/11/2020
Please read the patient information leaflet for this medicine fully before use:
Side effects & Warnings

Side effects 

Like all medications, Pramipexole can cause side effects. The majority of people won’t be impacted, but it’s important to familiarise yourself with what they look like should they arise. 

Very common (more than 1 in 10 people)


Common: (up to 1 in 10 people) 

Changes in sleep patterns such as insonia and sleepiness, fatigue, headache, abnormal or vivid dreams, constipation, dizziness or vomiting. 

Uncommon (up to 1 in 100 people) 

Urge to behave unusually, cardiac failure, inappropriate antidiuretic hormone secretion, dyskinesia, inability to keep still, restlessness, paranoia, delusion, amnesia, hallucinations, sleepiness during the day, falling asleep unexpectedly, weight gain, hypotension, peripheral oedema, allergic reaction, faiting, visual impairment, weight loss, decreased appetite, breathing difficulties, hiccups, lung infection. 

Some people may also encounter an inability to resist strong impulses or desires, which can include behaviours such as; an impulse to gamble excessively despite financial consequences, altered or increased sexual desire, uncontrollable shopping or spending, excessive eating or binge eating, mania or delirium. 

Frequency unknown

After cessation of treatment, dopamine agonist withdrawal of which symptoms may include depression, apathy, anxiety, fatigue, sweating or pain. 

Taking it with other medicines

It’s highly important you disclose to your prescriber any medication you take or have taken. Some treatments cannot be taken alongside others, as they can interfere with each other’s effectiveness or cause unknown side effects. This includes herbal, over-the-counter and recreationally taken drugs. 

Particularly tell your prescriber if you take anything to treat stomach acid or stomach ulcers, Parkinson’s disease medication, treatment for irregular heartbeats, AIDS medication, any cancer treatment, any medication for the prevention of painful night-time leg cramps, malaria treatment or if you’re taking a medication called levodopa. 

Conditions to look out for

It is vital you make your doctor aware of any pre-existing medical conditions. Particularly make them aware if you’ve ever suffered with kidney disease or problems, hallucinations, dyskinesia, dystonia, sleepiness and episodes of suddenly falling asleep, psychosis, visual impairment, heart or blood vessel problems or augmentation. 

Pregnancy and breastfeeding

Talk to your doctor if you’re pregnant or trying for a baby. You should not take this treatment if you are breastfeeding. 

Driving and using machinery

This medication can cause certain side effects which may potentially inhibit on the ability to properly drive. This may include drowsiness, tiredness, hallucinations or restlessness. If you encounter any of these side effects, you should refrain from driving or operating machinery. 

Food, drink and alcohol

Exercise strict caution in relation to the consumption of alcohol while you’re taking this medication. 

Page last reviewed:  12/11/2020
Please read the patient information leaflet for this medicine fully before use:

Can I still drink alcohol? 

Caution is recommended if mixing alcohol and Pramipexole. 

Will I still be able to drive?

Not if you encounter any side effects which impede on that ability. 

Can I take this medication while pregnant? 

This will depend how well you receive the treatment, and will come down to a unique discussion between yourself and a doctor or prescriber. You shouldn’t take this treatment if you are breastfeeding. 

How should I store it? 

There are no specific storage instructions for Pramipexole. Keep away from children in a dry environment, and do not use after the expiry date. 

Is it available over-the-counter? 

No, Pramipexole is a prescription only treatment. 

Can I buy Pramipexole for restless legs syndrome online? 

Yes. Take our medical questionnaire to have your symptoms assessed by one of our GMC-registered doctors or GPhC-registered prescribers. Where appropriate, prescriptions will be issued and your treatment dispensed at our UK pharmacy. 

Page last reviewed:  12/11/2020 is rated 4.9 out of 5 by 3131 customers on TrustPilot!
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