Duloxetine
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Reviewed on September 21, 2026. by Dr Daniel Atkinson Clinical Reviewer Registered with GMC (No. 4624794) Next review due on Jan 01, 1970.
Dr Daniel Atkinson

Last updated on September 21, 2026.

Product info

  • Duloxetine is an SNRI that works by upping levels of serotonin and norepinephrine in your nervous system.

  • It can help improve symptoms of anxiety and depression in 2 to 4 weeks.
  • You may continue to take it after you feel better to stop depression or anxiety from coming back.

Price checker

20mg Out of stock
$36.95 30 Capsules
  • Prices include:
    Express shipping

    2-5 day shipping by secure courier

  • Consultation + Access to our clinicians

    Ask our experts anything you like, any time you want.

  • Total
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    Save $0.00 each order
Duloxetine Duloxetine hydrochloride

What is Duloxetine?

Duloxetine is a type of SNRI, which stands for serotonin and norepinephrine reuptake inhibitor. This means it targets serotonin and norepinephrine (two chemical messengers in your brain) to help improve your mood and energy.

How does Duloxetine work?

Duloxetine inhibits the reabsorption of neurotransmitters called serotonin and norepinephrine, leaving more of these chemical messengers active in the brain.[3] Serotonin is involved in regulating your mood, sleep and appetite,[1] while norepinephrine affects attention and alertness.[2] With more of these neurotransmitters available, Duloxetine can help improve your general mood, help regulate your sleep, and increase your energy and focus.

What doses does Duloxetine come in?

Duloxetine comes in 20 mg, 30 mg, 40 mg, 60 mg, 90 mg and 120 mg tablets. You’ll typically start on a low dose of Duloxetine, and slowly increase your dose as needed until you reach a point where symptoms of depression and anxiety are effectively managed.

If you find that after moving up a dose you’re experiencing more side effects, speak to your clinician. They may recommend moving back down a dose to reduce the risk of any adverse effects.

Treated trusted source:

  1. Bamalam, O.A. Moore, M.J. Khalili, Y.A. (2023). Physiology, Serotonin. StatPearls. Treasure Island (FL): StatPearls Publishing.
  2. Holland, N. Robbins, T.W. Rowe, J.B. (2021). The role of noradrenaline in cognition and cognitive disorders. Brain. 144(8). pp. 2243-2256.
  3. Berardis, D.D. (2008). The role of duloxetine in the treatment of anxiety disorders. Neuropsychiatric Disease and Treatment. 4(5). pp. 929-935.
Dr Daniel Atkinson 719
This page was medically reviewed by Dr Daniel Atkinson on No date provided. Next review due on No date provided.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Duloxetine Duloxetine hydrochloride

How to take Duloxetine

You should always take Duloxetine exactly as you’ve been instructed to by your clinician. You’ll usually take one tablet of Duloxetine once each day with a drink of water. You’ll typically start by taking either 30 mg or 60 mg of Duloxetine, but this can be adjusted up or down depending on your response to the medicine and how well it helps to manage your mental health.

Don’t stop taking Duloxetine or make changes to how much you take without consulting your clinician first.

How long does it take for Duloxetine to work?

Duloxetine should start to help with symptoms of depression or anxiety within two weeks of taking it – but it can take between two to four weeks before you start to feel better.[1] If four weeks have passed and you don’t feel any better, speak to your doctor – they may be able to recommend alternative treatment options.

What should I do if I make a mistake taking Duloxetine?

If you take more Duloxetine than you’ve been prescribed by your clinician, get medical attention right away. Symptoms caused by taking too much Duloxetine could include:

  • Sleepiness
  • Coma
  • Serotonin syndrome (a rare response that can cause feelings of happiness, drowsiness, clumsiness, restlessness, feeling like you’re drunk, fever, sweating or rigid muscles)
  • Seizures
  • Vomiting
  • An elevated heart rate

If you’ve forgotten to take Duloxetine, take the missed dose when you remember. But if your next scheduled dose is soon, skip the missed one and carry on as usual from the upcoming dose. Don’t take a double dose of Duloxetine to make up for it, and never take more than the amount of Duloxetine you’ve been prescribed in a day.

Treated trusted source:

  1. U.S. National Library of Medicine. (2024). Duloxetine: MedlinePlus Drug Information.
Dr Daniel Atkinson 719
This page was medically reviewed by Dr Daniel Atkinson on No date provided. Next review due on No date provided.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Duloxetine Duloxetine hydrochloride

Duloxetine isn’t suitable for everyone, and there are some things that you need to be aware of when using it.

Here’s all the official info on it. If anything is unclear, let our clinician know, and they can talk with you about it.

Duloxetine Duloxetine hydrochloride

Duloxetine: FAQ

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

Does Duloxetine have any side effects?

Answer:
Duloxetine has a risk of some associated side effects, but they won’t affect everyone who takes it. Duloxetine’s side effects aren’t usually severe, and they often fade after a short time taking the medicine.

The most common side effects reported by people using Duloxetine (that affect more than one in ten people) are:

  • Nausea

  • Dry Mouth

  • Sleepiness

  • Headaches


Other common side effects of Duloxetine (that can affect up to one in ten people) are:

  • Reduced appetite

  • Difficulty sleeping

  • Agitation

  • Lowered sex drive

  • Anxiety

  • Dizziness

  • Feeling sluggish or sleepy

  • Tremor

  • Numbness

  • Pricking or tingling of the skin

  • Blurred vision

  • Dizziness

  • Increased blood pressure

  • Diarrhea

  • Stomach pain

  • Vomiting

  • Heartburn or indigestion

  • Sweating

  • Weakness

  • Shivering


This isn’t a full list of every side effect associated with taking Duloxetine. If you’ve got any questions, take a look at the patient package insert, or contact your clinician for advice.

What time should I take Duloxetine?

Answer:
There isn’t a specific time you should try to take Duloxetine, just try to do it at the same time each day. This makes it easier to remember, and ensures the level of medicine in your system stays steady. If you find that Duloxetine makes you drowsy, it might be best to try and take it in the evening. But if you find sleeping more difficult after taking Duloxetine, taking it in the morning might suit you better.

Are there any alternatives to Duloxetine?

Answer:
Venlafaxine is another type of SNRI that works in a very similar way to Duloxetine (by increasing the levels of serotonin and norepinephrine available in your brain). But because everyone responds to different medications in different ways, you might find that one works better for you (even if the other hasn’t been effective).

A review of studies comparing Duloxetine and Venlafaxine found that Venlafaxine may be a preferred option for short-term treatment of major depression in people who haven’t responded well to selective serotonin reuptake inhibitors (SSRIs).[1]

Can you drink alcohol while on Duloxetine?

Answer:
It’s usually recommended that you try to avoid alcohol while taking Duloxetine, as it can increase the risk of side effects. If you do decide to drink while on Duloxetine, make sure to take extra care, and try to keep the amount you consume to a minimum.

Can you take Duloxetine long-term?

Answer:
Taking Duloxetine long-term is generally thought to be safe for most people when you stick to your prescriber’s instructions.

But for older individuals who already have pre-existing cardiovascular problems, there’s some evidence that long-term use could cause significant cardiovascular risks.[2] You may have to undergo regular cardiovascular monitoring to ensure that Duloxetine isn’t causing any heart problems, and if it is, you might have to reduce your dose or stop taking it altogether.

Treated trusted source:

  1. Schueler, Y.B. (et al.) (2011). A systematic review of duloxetine and venlafaxine in major depression, including unpublished data. Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews. York (UK): Centre for Reviews and Dissemination.
  2. Cui, Y. et al. (2024). The Long-Term Cardiovascular Risks of Duloxetine Use in Older Adults: A Retrospective Medical Record-Based Adverse Drug Reaction Assessment. Journal of Clinical Medicine. 13(24). p. 7595.

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