Nortriptyline
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Reviewed on September 22, 2026. by Dr Daniel Atkinson Clinical Reviewer Registered with GMC (No. 4624794) Next review due on Jan 01, 1970.
Dr Daniel Atkinson

Last updated on September 22, 2026.

Product info

  • Nortriptyline is a tricyclic antidepressant that helps treat depression.

  • It increases serotonin and norepinephrine levels in your brain.
  • It comes in three strengths: 10 mg, 25 mg, and 50 mg

Price checker

10mg Out of stock
$35.95 30 Capsules
  • Prices include:
    Express shipping

    2-5 day shipping by secure courier

  • Consultation + Access to our clinicians

    Ask our experts anything you like, any time you want.

  • Total
    $35.95
    Save $0.00 each order
Nortriptyline Nortriptyline

What is Nortriptyline?

Nortriptyline is a tricyclic antidepressant that helps treat depression. Unlike SSRIs (selective serotonin reuptake inhibitors), which primarily target serotonin, tricyclic antidepressants have a broader effect on the brain, which increases the risk of side effects. But they can be beneficial for people if SSRIs didn’t work for them. It comes in three strengths, and you typically take 10 mg three times a day.

How does Nortriptyline work?

Nortriptyline works by blocking the reuptake of serotonin and norepinephrine, two neurotransmitters important for regulating mood.

Serotonin affects your mood, sleep, and overall well-being, while norepinephrine regulates stress, anxiety, and mood. Low levels of both neurotransmitters can cause symptoms of depression.

By blocking the reuptake of these neurotransmitters, higher levels remain in the brain, which improves your mood and overall well-being.[1]

What doses of Nortriptyline are there?

Nortriptyline comes in three strengths of 10 mg, 25 mg, and 50 mg. You typically start on a low dose of 10 mg three times a day, and if necessary, it may be increased to a higher dose of 75 mg to 100 mg. Older adults will start on a lower dose because they can be more sensitive to the medication. Your healthcare provider will determine the best dose for you based on your symptoms and how well the drug is working for you.

Treated trusted source:

  1. Merwar G, et al. Nortriptyline. [2023]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing.
Dr Daniel Atkinson 719
This page was medically reviewed by Dr Daniel Atkinson on No date provided. Next review due on No date provided.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Nortriptyline Nortriptyline

How to take Nortriptyline

Swallow the tablet whole with water. It can be taken with or without food. It’s best to take the tablet at the same time each day for optimal effectiveness.

If you’re taking multiple doses daily, split them evenly throughout the day. If you’re unsure how to take it, you can contact your healthcare provider for guidance.

How long does Nortriptyline take to work?

Nortriptyline is absorbed relatively quickly, but it can take a few weeks or even months for your mood and symptoms to improve. This is because, although the medication is absorbed, it may take time to build a steady concentration of serotonin and norepinephrine in the brain to produce a noticeable effect. You should continue taking Nortriptyline even if you don’t feel better right away. If, after 12 weeks, you feel no difference, contact your healthcare provider.

Dr Daniel Atkinson 719
This page was medically reviewed by Dr Daniel Atkinson on No date provided. Next review due on No date provided.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Nortriptyline Nortriptyline

Nortriptyline isn’t suitable for everyone, and there are some things that you need to be aware of when taking it.

Here’s all the official info on it. If anything is unclear, let our healthcare provider know, and they can talk with you about it.

Nortriptyline Nortriptyline

Nortriptyline: FAQ

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

Will I get side effects with Nortriptyline?

Answer:
Some people get side effects while taking Nortriptyline, although not everyone will experience them. These may include:

  • Dry mouth

  • Excessive sweating

  • Constipation

  • Nausea

  • Headache

  • Tremor

  • Dizziness


For the full list of side effects, check the patient package insert that comes with your medication.

Can I take Nortriptyline while pregnant?

Answer:
You shouldn’t take Nortriptyline if you're pregnant, because it could cause withdrawal symptoms in your baby, such as irritability and tremors. A healthcare provider will only recommend taking Nortriptyline during pregnancy if they think it’s absolutely necessary.

If you become pregnant while taking Nortriptyline, let your healthcare provider know right away. Don't stop taking the medication without your healthcare provider knowing, because this could cause withdrawal symptoms.

Similarly, avoid taking Nortriptyline while breastfeeding, because it can pass into breast milk and potentially affect your baby.

How well does Nortriptyline work for depression?

Answer:
Nortriptyline is an antidepressant that can be effective for some people. In one study, patients with treatment-resistant depression were given Nortriptyline for six weeks.[1] After the treatment period, around one-third of the patients showed improved symptoms. While this may seem like a low percentage, treating depression is complex, and what works for one person may not work for another. Additionally, the study included patients who were resistant to treatment, which may explain why Nortriptyline was less effective for them.

How does Nortriptyline affect blood pressure?

Answer:
Nortriptyline can block alpha-adrenergic receptors in blood vessels, which reduces the blood vessels' ability to narrow normally. This can cause a drop in blood pressure, particularly when standing up from a lying or sitting position. This is called orthostatic hypotension. Older adults may be more susceptible to these effects because they can be more sensitive to changes in blood pressure.

How do I stop taking Nortriptyline?

Answer:
You should only stop taking Nortriptyline with the guidance of your healthcare provider. Stopping abruptly can lead to withdrawal symptoms, such as insomnia, excessive sweating, and irritability.

If you want to stop, let your healthcare provider know, and they’ll gradually lower your dose to help prevent these symptoms.

Treated trusted source:

  1. Tedlow, M.F.A.A.N.G.I.P.J.E.A.J.J.W.T.P.K.E.K.B.M.I.J. (2003). Nortriptyline for treatment-resistant depression. [online] Psychiatrist.com.

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