Venlafaxine ®
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Reviewed on September 22, 2026. by Dr Daniel Atkinson Clinical Reviewer Registered with GMC (No. 4624794) Next review due on Jan 01, 1970.
Dr Daniel Atkinson

Last updated on September 22, 2026.

Product info

  • Venlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI).

  • It increases serotonin and norepinephrine levels in your brain.
  • It’s typically taken daily and the tablets come in four doses.

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37.5mg Out of stock
$35.95 30 Tablets
  • Prices include:
    Express shipping

    2-5 day shipping by secure courier

  • Consultation + Access to our clinicians

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Venlafaxine Venlafaxine

What is Venlafaxine?

Venlafaxine is a treatment for mental health conditions, such as depression and social anxiety. It’s a serotonin-norepinephrine reuptake inhibitor (SNRI), which works by increasing serotonin and norepinephrine levels. It’s typically taken once a day and is available in multiple doses.

How does Venlafaxine work?

Serotonin and norepinephrine are two neurotransmitters important for your mood and sleep. Low levels of them contribute to poor mental health.

Venlafaxine works by blocking the proteins that reabsorb serotonin and norepinephrine. This allows more to remain in the central nervous system, leading to higher energy levels and a better mood.[1]

What doses of Venlafaxine are there?

Venlafaxine is available in multiple doses: 37.5 mg, 75 mg, 150 mg, and 225 mg. The typical starting dose is 75 mg a day (or 37.5 mg for certain conditions). The maximum dose is 375 mg a day.

Treated trusted source:

  1. Singh, D. and Saadabadi, A. (2024). Venlafaxine. PubMed.
Dr Daniel Atkinson 719
This page was medically reviewed by Dr Daniel Atkinson on No date provided. Next review due on No date provided.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Venlafaxine Venlafaxine

How to take Venlafaxine

Swallow Venlafaxine whole with water; don’t crush, chew, or dissolve the tablet. It should be taken with food. Take it around the same time each day, either in the morning or evening.

Don’t stop taking Venlafaxine without your clinician’s consent. Stopping suddenly can lead to withdrawal symptoms such as tiredness, aggression, and nightmares. If you want to stop, let your clinician know, and they’ll help gradually reduce your dose.

How long does Venlafaxine take to work?

Venlafaxine is absorbed relatively quickly (within a few hours), but it can take up to two weeks to start seeing the benefits.[1] Initially, your mood and anxiety might improve. By week six, you should feel the full effects of the medicine. If you don’t feel better after six weeks, let your clinician know; they may increase your dose or recommend alternative treatments.

What should I do if I make a mistake when taking Venlafaxine?

If you took more than the recommended dose of Venlafaxine, seek medical attention immediately. Taking too much Venlafaxine can be life-threatening, especially if taken with alcohol or other substances.

If you forget to take Venlafaxine, don’t worry. Take it as soon as you remember, unless it’s nearly time for your next scheduled dose. In that case, skip the missed dose and continue taking your medicine as normal.

Treated trusted source:

  1. Khan, A., et al. (1998). The Use of Venlafaxine in the Treatment of Major Depression and Major Depression Associated With Anxiety. Journal of Clinical Psychopharmacology, 18(1), pp.19–25.
Dr Daniel Atkinson 719
This page was medically reviewed by Dr Daniel Atkinson on No date provided. Next review due on No date provided.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Venlafaxine Venlafaxine

Venlafaxine isn’t suitable for everyone, and there are some things that you need to be aware of when taking it.

Here’s all the official info on it. If anything is unclear, let our clinician know, and they can talk with you about it.

Venlafaxine Venlafaxine

Venlafaxine: FAQ

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

What are the side effects of Venlafaxine and how long do they last?

Answer:
You may experience side effects with Venlafaxine, although not everyone will experience them. Very common side effects include:

  • Headache

  • Drowsiness

  • Dizziness

  • Insomnia

  • Dry mouth

  • Constipation

  • Nausea

  • Sweating


The side effects should subside as your body adjusts to the medicine, which may take a few weeks. But if you find them too difficult to manage, or they persist longer than a month, let your clinician know.

To help with:

  • Nausea and constipation: Consume small portions of bland foods throughout the day, instead of three main meals a day.

  • Dry mouth: Regularly sip water, chew sugar-free gum, or suck on hard candy.

Does Venlafaxine make you sleepy?

Answer:
Insomnia and drowsiness are common side effects of Venlafaxine, so you may feel tired during the day, especially if you’re not getting quality sleep. Taking the medication in the evening can help reduce daytime drowsiness and may help you sleep better. While these side effects can be inconvenient, they should only last for a few weeks until your body adjusts to the medicine.

What is the half-life of Venlafaxine?

Answer:
Venlafaxine has two different half-lives because it’s primarily broken down into an active metabolite called O-desmethylvenlafaxine (ODV). Venlafaxine itself has a half-life of around 5 hours for the immediate-release tablets and about 7 to 11 hours for the extended-release formulations, while ODV has a half-life of around 11 hours.[1]

Because both have relatively short half-lives, venlafaxine should be taken every day. This ensures its levels stay consistent in your body, helping you get the best from it. Missing even one day's dose can cause drug levels to fall significantly, which is why some people begin to experience withdrawal symptoms after only one missed dose.

How well does Venlafaxine work?

Answer:
Venlafaxine is an effective treatment for mental health conditions, including depression and generalized anxiety disorder.

A 12-week study involving 384 patients taking venlafaxine for depression found significant health outcomes within two weeks, especially with a dosage of 150 mg to 200 mg. As the treatment continued, the benefits also persisted. While side effects were common, venlafaxine was generally found to be well tolerated.[2]

Additionally, other studies have shown it to be useful and effective in treating anxiety associated with social phobia, obsessive-compulsive disorder, and panic disorder.[3]

What drug class does Venlafaxine belong to?

Answer:
Venlafaxine belongs to the serotonin-norepinephrine reuptake inhibitor (SNRI) class of medications. These drugs help increase the levels of serotonin and norepinephrine in the central nervous system.

This differs from other common antidepressants such as Escitalopram (Lexapro), Fluoxetine (Prozac), and Paroxetine (Paxil), which belong to the class of drugs known as selective serotonin reuptake inhibitors (SSRIs).

The main difference between the two classes is that SSRIs primarily increase serotonin levels, while SNRIs increase both serotonin and norepinephrine levels.

Treated trusted source:

  1. Dailymed (2024). DailyMed – venlafaxine hydrochloride capsule, extended release. Nih.gov.
  2. Khan, A., et al. (1998). The Use of Venlafaxine in the Treatment of Major Depression and Major Depression Associated With Anxiety. Journal of Clinical Psychopharmacology, 18(1), pp.19–25.
  3. Hackett, D. (2000). Venlafaxine XR in the treatment of anxiety. Acta psychiatrica Scandinavica. Supplementum, [online] (406), pp.30–5.

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