Zomig, containing the active ingredient zolmitriptan, belongs to a class of medicines called selective serotonin receptor agonists (or, more informally, triptans). Triptans like Zomig are licensed specifically for relieving the symptoms of migraine. You take it as soon as you start to get symptoms, and it typically gets to work to help you feel better in under two hours.
Zomig wonโt prevent or reduce the number of migraines that you get, and it wonโt provide relief for other headaches or pain.
How does Zomig work?
The exact cause of migraines isnโt fully understood, but itโs thought that temporary changes to your brain cause its blood vessels to widen. Often this can be due to a โtriggerโ, but sometimes they can appear without a reason or warning.
Zomig works to reverse the effects of migraines by binding to the serotonin receptors on your brain and narrowing your blood vessels. This then reduces the transmission of pain signals and eases your symptoms.
What doses of Zomig are there?
You can get Zomig in either 2.5mg or 5mg doses. The dose that youโll be prescribed will depend on your health needs, your symptoms and the form of treatment that you want to take. Zomig tablets are only available in 2.5mg doses and the nasal spray is only available in 5mg doses.
This page was written by The Treated Content Team.
This page was medically reviewed by Dr. Joseph Palumbo on November 28, 2024. Next review due on November 28, 2027.
How we source info.
When we present you with stats, data, opinion or a consensus, weโll tell you where this came from. And weโll only present data as clinically reliable if itโs come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
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How to take Zomig tablets
You should always follow the advice of our clinician when taking Zomig.
To take it, simply swallow one tablet whole, with water, once your symptoms have started. If the migraine is still present, or returns, you can take another tablet after two hours. Donโt take more than two tablets or 10mg in a day unless youโve been told otherwise by your clinician.
How to use Zomig nasal spray
Zomig spray comes in ready-to-use spray units. Each unit contains 5mg of zolmitriptan, and is for single-use only. The recommended dose is to use one spray in just one of your nostrils – it doesnโt matter which one. If the migraine is still present or returns, you can take another dose after two hours. Donโt use more than two sprays (10mg) in one day.
To use Zomig spray:
gently blow your nose
remove the protective cover
hold the spray with your thumb underneath and two fingers either side of the nozzle
block one nostril by placing your finger on one side of your nose
put the nozzle into the other nostril, as far as feels comfortable
tilt your head back slightly and close your mouth
whilst breathing in gently with your nose, press the plunger firmly with your thumb. The plunger might feel stiff, and you may feel a click
remove the nozzle from your nose whilst keeping your head tilted back
breathe gently through your mouth for five to ten seconds. You may feel some liquid inside your nose, this is normal and doesnโt mean that it hasnโt worked
How long does it take Zomig to work?
Zolmitriptan, the active ingredient in Zomig, has a rapid onset of action – with significant headache relief observed in clinical trials in under 15-30 minutes of taking it.[1]
What should I do if I make a mistake when taking Zomig?
If you take too much Zomig, or accidentally swallow the contents of the nasal spray, you should seek medical help and advice straight away. If the nasal spray gets into your eye, wash it out straight away with clean water.
Treated trusted source:
Charlesworth, B.R., et al., (2003).Speed of Onset and Efficacy of Zolmitriptan Nasal Spray in the Acute Treatment of Migraine. CNS Drugs, [online] 17(9), pp.653โ667.
This page was written by The Treated Content Team.
This page was medically reviewed by Dr. Joseph Palumbo on November 28, 2024. Next review due on November 28, 2027.
How we source info.
When we present you with stats, data, opinion or a consensus, weโll tell you where this came from. And weโll only present data as clinically reliable if itโs come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
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Zomig isnโt suitable for everyone, and there are some things that you need to be aware of when taking it.
Hereโs all the official infoon it. If anything is unclear, let our clinician know, and they can talk with you about it.
ZomigZolmitriptan
Zomig: FAQ
Have something specific you want to know? Search our info below, or ask our experts a question if you canโt find what youโre looking for.
Which version of Zomig should I use?
Answer:
Whether you take Zomig tablets or the nasal spray is down to a matter of personal preference. Some evidence has shown that the nasal spray is more effective than the tablets,[1] but you should consider what you find to be the most comfortable and suitable option for you.
How is Zomig different from other migraine treatments?
Answer:
Most migraine treatments come in the form of triptans, of which the method of action for treating migraines is largely the same. Some triptans, however, suit some people better than others, and differ in both how long they take to work and how long they stay in your system.
One thing that sets Zomig apart from many other triptans, though, is that it is available in the form of a nasal spray. This may suit you better if you prefer not to take a tablet.
Is Zomig similar to any other treatments?
Answer:
Thereโs a generic version of Zomig, which goes by the name of its active ingredient: Zolmitriptan. Both of these treatments will work in much the same way to treat your symptoms, theyโll just be made in different labs and marketed differently.
Do I need a prescription for Zomig?
Answer:
Yes, you need a prescription for Zomig. This is because triptans are only suitable to treat migraines rather than other headaches or pains, so a clinician is going to want to make sure that your diagnosis is accurate before dispensing the medication to you.
Our experts continually monitor new findings in health and medicine, and we update our articles when new info becomes available.
Jan 20, 2026
Published by: The Treated Content Team.Medically reviewed by: Dr. Joseph Palumbo, Senior Medical Adviser
How we source info.
When we present you with stats, data, opinion or a consensus, weโll tell you where this came from. And weโll only present data as clinically reliable if itโs come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
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Dr. Joseph Palumbo
Senior Medical Adviser
Joseph joined Treated in 2023, and is one of the lead doctors providing prescribing services for the platform.
When we present you with stats, data, opinion or a consensus, weโll tell you where this came from. And weโll only present data as clinically reliable if itโs come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
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