Epiduo ®
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Reviewed on Oct 7, 2026. by Ms Sanjeda Chowdhury Superintendent Pharmacist + Independent Prescriber Registered with GPhC (No. 2202465) Next review due on Oct 05, 2029.
Ms Sanjeda Chowdhury

Last updated on Oct 07, 2026.

Increases cell turnover and prevents new breakouts.

Epiduo is a dual-action acne treatment. It contains adapalene, a retinoid, and benzoyl peroxide, an antiseptic.

Price checker

0.30% gel
$1,199.95 45 g bottle
  • Prices include:
    Express shipping

    2-5 day shipping by secure courier

  • Consultation + Access to our clinicians

    Ask our experts anything you like, any time you want.

  • Total
    $1,199.95
    Save $0.00 each order
Epiduo Epiduo

What is Epiduo?

Epiduo is a dual-action treatment for acne. Its two active ingredients, adapalene, a retinoid, and benzoyl peroxide, an antiseptic, work together to reduce spots, inflammation, and hyperpigmentation. Epiduo is available in two strengths and is typically applied every day, although this may vary based on the severity of your acne and your skin’s sensitivity.

How does Epiduo work?

Epiduo contains two active ingredients, each working differently to treat acne.

  • Adapalene is a retinoid that increases cell turnover. This means that old skin is shed more quickly, making way for new skin. This process helps clear old spots and reduce hyperpigmentation. Additionally, it relieves redness and swelling associated with acne. Adapalene can also prevent future spots from developing.[1]
  • Benzoyl peroxide is an antiseptic that targets the bacteria responsible for acne, preventing new breakouts. It also helps remove excess oil and alleviates inflammation, swelling, and redness.[2]

Because of the way Epiduo works, it’s an effective treatment for acne, with studies showing that over 90% of patients show improvement.[3]

Is Epiduo similar to Benzoyl peroxide?

In a way, yes. This is because Epiduo contains benzoyl peroxide (alongside adapalene). While benzoyl peroxide can be used as a standalone treatment for acne, Epiduo is generally thought to be more effective.

What doses of Epiduo are there?

Epiduo comes in two strengths: 0.1% adapalene and 2.5% benzoyl peroxide, or 0.3% adapalene and 2.5% benzoyl peroxide. It’s typically applied as a thin layer every evening.

Treated trusted source:

  1. Tolaymat L, Dearborn H, Zito PM. Adapalene. [2023]. In: StatPearls [Internet]. Treasure Island.
  2. Czyz, S., Yang, K., & Jafarian, F. (2025). Benzoyl peroxide in the treatment of acne: Are there potential health concerns? Frontiers in Pediatrics, 13, 1599491.
  3. Czyz, S., et al. (2025). Benzoyl peroxide in the treatment of acne: Are there potential health concerns? Frontiers in Pediatrics, 13, 1599491.
Ms Sanjeda Chowdhury 2517099
This page was medically reviewed by Ms Sanjeda Chowdhury on October 05, 2026. Next review due on October 05, 2029.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Epiduo Epiduo

How to take Epiduo

Apply a thin layer of gel over the affected areas at bedtime. If you’re pairing it with a moisturizer, apply the gel first, let it dry, and then apply the moisturizer. If you have sensitive skin, you may be advised to use the moisturizer before applying the gel.

It’s normal to feel a mild reaction when you first start using it, but if it persists or if you experience more irritation or a severe reaction, let your physician know. They may lower your dose or recommend an alternative treatment.

Ms Sanjeda Chowdhury 2517099
This page was medically reviewed by Ms Sanjeda Chowdhury on October 05, 2026. Next review due on October 05, 2029.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Epiduo Epiduo

Epiduo isn’t suitable for everyone, and there are some things that you need to be aware of when taking it.

Here’s all the official info on it. If anything is unclear, let our doctor know, and they can talk with you about it.

 

Epiduo Epiduo

Epiduo: FAQ

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

How long does Epiduo take to work?

Answer:
It might take a few weeks to notice an improvement in your symptoms and even longer for them to completely clear. In one study, patients reported improvement around the two-week mark, but this can vary for everyone.[1]

Some people might also experience worsening symptoms in the first few weeks of using Epiduo. This is because it contains a retinoid, which speeds up the shedding process. During this time, ‘hidden’ or under-the-skin spots can come to the surface, making it seem like your acne is getting worse. But as you continue using the medication, it should clear up over time.

Additionally, while active spots might clear up within a few weeks, the hyperpigmentation left behind by these spots can take longer to fade.

How does Epiduo compare with Adapalene?

Answer:
Epiduo contains the active ingredient adapalene, which is a retinoid. You can get adapalene as a standalone treatment or paired with other medications, such as niacinamide. Epiduo is believed to be more effective than adapalene alone because it has a broader effect.

How well does Epiduo work for acne?

Answer:
In one study, 2,780 patients used Epiduo and were instructed to apply it daily for 12 weeks. After this period, over 90% of patients reported improvements, with many noticing changes at the two-week mark. Approximately 20% of patients had complete improvements within 12 weeks.

Epiduo is also a tolerable treatment, with over 60% of patients sticking to the medication. While many experienced side effects, most were mild and manageable, and didn't lead to serious problems.[1]

Will I get side effects using Epiduo?

Answer:
Yes, you might experience side effects when using Epiduo, although not everyone will. Side effects may include:

  • Dry skin

  • Local rash 

  • Burning sensation

  • Skin irritation 

  • Skin redness

  • Scaling


These side effects tend to be mild and usually occur in the first few weeks of treatment. They should subside as your body adjusts to the medication. Using a moisturizer before applying Epiduo can help relieve side effects, especially if your skin is more sensitive.

Can I get Epiduo through private health insurance?

Answer:
It depends on your private insurance plan. Certain insurers only cover specific medications, so it’s always best to ask your provider whether they cover your preferred treatment.

Treated trusted source:

  1. Czyz, S., et al. (2025). Benzoyl peroxide in the treatment of acne: Are there potential health concerns? Frontiers in Pediatrics, 13, 1599491.

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