EpiPen ®
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300mcg
$429.95 1 Pen
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Reviewed on Sep 24, 2026. by Dr. Joseph Palumbo Senior Medical Adviser Registered with NPI (No. 1043478878) Next review due on Sep 21, 2029.
Dr. Joseph Palumbo

Last updated on Sep 24, 2026.

Epinephrine injection to get allergic emergencies under control.

Brand-name emergency adrenaline injection to manage life-threatening allergic reactions, also known as anaphylaxis. It helps neutralize your body’s immune response, relaxes your airways to make breathing easier, and raises your blood pressure.

Price checker

300mcg
$429.95 1 Pen
  • Prices include:
    Express shipping

    2-5 day shipping by secure courier

  • Consultation + Access to our clinicians

    Ask our experts anything you like, any time you want.

  • Total
    $429.95
    Save $0.00 each order
EpiPen Epinephrine

What is an EpiPen?

EpiPen is an automatic injector device that delivers a dose of epinephrine (also known as adrenaline). It’s used to treat emergency allergic reactions (anaphylactic shock) quickly. Anaphylactic shock is an immune response to an allergen that causes your body to release chemicals that can trigger symptoms like:

  • Swelling of the lips, face, tongue or throat
  • Difficulty breathing or swallowing
  • A sudden drop in blood pressure
  • Feeling faint, dizzy, or losing consciousness
  • Itchy skin
  • Red, raised rashes
  • Stomach pain, nausea or diarrhea

How does EpiPen work?

When someone goes into anaphylactic shock, the airways narrow (making breathing difficult) and blood vessels open up (suddenly dropping blood pressure). EpiPen injections relax the muscles around your airways, opening them back up, and cause blood vessels to constrict, raising blood pressure.[1] This counteracts the life-threatening symptoms of an emergency allergic reaction until you can get further treatment.

How do EpiPen doses work?

EpiPens come in one dose, a 300 mcg auto-injector device. This makes delivering epinephrine quickly in an emergency situation easier. EpiPens are single use, so if the allergic reaction is severe, a second EpiPen might need to be used 15 minutes after this first one. This means it’s important to carry two pens, just in case you need a second dose.

What is the active ingredient in EpiPen?

EpiPen’s active ingredient in epinephrine, also known as adrenaline. It’s a natural hormone your body produces when experiencing stress or fear. It treats anaphylaxis by opening up your airways, reducing swelling, and raising your blood pressure to neutralize the symptoms of a severe allergic reaction.

Treated trusted source:

  1. MedlinePlus (2023). Epinephrine injection: MedlinePlus drug information. MedlinePlus.
Dr. Joseph Palumbo 29191
This page was medically reviewed by Dr. Joseph Palumbo on September 21, 2026. Next review due on September 21, 2029.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

EpiPen Epinephrine

How to take EpiPen

It’s important to make sure you’re familiar with how to use your EpiPen so that you’re prepared for an emergency.

  • Lie down if possible, with your legs elevated to promote blood flow
  • Remove the safety cap from the EpiPen
  • Place the orange tip of your EpiPen around 10 cm from your outer thigh.
  • Push the tip of your EpiPen firmly into your outer thigh at a 90° angle (this can be done through clothes)
  • You’ll hear a clicking sound telling you that the epinephrine has been released
  • Hold your EpiPen in place for three seconds
  • Call (or have someone around you call) for emergency medical assistance
  • If your symptoms haven’t gotten better after 5-15 minutes, use a second EpiPen in the exact same way as above
Dr. Joseph Palumbo 29191
This page was medically reviewed by Dr. Joseph Palumbo on September 21, 2026. Next review due on September 21, 2029.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

EpiPen Epinephrine

EpiPen isn’t suitable for everyone, and there are some things that you need to be aware of when taking it.

Here’s all the official info on it. If anything is unclear, let our clinician know, and they can talk with you about it.

EpiPen Epinephrine

EpiPen: FAQ

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

Are there any alternatives to EpiPen?

Answer:
Yes, there are some alternative emergency treatments for anaphylaxis available in the US – but they all use epinephrine. So it’ll come down to the one you find most comfortable to use in an emergency situation.

AUVI-Q is another auto-injector treatment, but it comes with a built-in electronic speaker that delivers step-by-step instructions on how to use it when the outer case is removed, so it can be easier for people unfamiliar with how to administer treatment to use in an emergency. It’s also smaller than an EpiPen, and rectangular in shape, which means it might be easier to carry in the pocket of your clothes.

Neffy is a needle-free alternative to an EpiPen. It’s a nasal spray that’s administered into one nostril instead of an injection. This means Neffy could be a good alternative if you’re uneasy around needles, which can delay treatment in an emergency situation.

How effective is EpiPen for anaphylaxis?

Answer:
Clinical studies have proved that EpiPen is an effective and life-saving treatment for anaphylaxis. A systemic review and meta analysis of studies found that 97.8% of allergic reactions respond to two doses of epinephrine.[1]

Do I need a prescription for an EpiPen?

Answer:
Yes. A doctor will need to check that you have a severe allergy and could be at risk of anaphylaxis before prescribing an EpiPen. Using an EpiPen incorrectly could result in serious problems with your heart and blood pressure.

How long does it take EpiPen to work for Anaphylaxis?

Answer:
Epipens start to work from the moment you inject the medication, but it can take 5-10 minutes before it reaches its full effect.[2] If your symptoms don’t improve within 5-15 minutes of using your EpiPen, you should administer another dose.

What should I do if I make a mistake when taking an EpiPen?

Answer:
If you use your EpiPen when you don’t need it, or if you accidentally use too much, you should get medical assistance right away. Taking epinephrine when you’re not experiencing an allergic reaction can cause your blood pressure to spike very quickly, and you’ll need to be monitored for your safety.

Accidentally injecting your EpiPen into your hands or fingers could also cause a lack of blood supply in these areas.

Does EpiPen cause side effects?

Answer:
Just like any medicine you take, EpiPen can cause side effects. The most common side effects when using an EpiPen include:

  • Increased heart rate

  • Paleness around the injection site

  • Coldness and numbness around the injection site

  • Bruising around the injection site

  • Bleeding or redness around the injection site

  • Skeletal injury


This isn’t a full list of every side effect reported by people using EpiPens. If you want to find out more, look at the package insert that comes with your medication, or speak with your doctor or pharmacist.

Can I get EpiPen through private health insurance?

Answer:
You may be able to get EpiPen through commercial insurance plans like Medicare Part D or Medicaid if you’ve been prescribed them by your doctor. But many insurance plans will only provide coverage for generic epinephrine injections over EpiPens. The good news is that generic epinephrine treatments are usually cheaper, which means lower copays for you to cover. Copay just means that your insurance provider will cover part of the cost of the medication, and you’ll cover the rest.

If you can’t get EpiPens through your health insurance, you should still be able to get them from an online pharmacy service if you have a severe allergy that could cause anaphylaxis.

Treated trusted source:

  1. Dribin, T.E. Waserman, S. Turner, P.J. (2023). Who Needs Epinephrine? Anaphylaxis, Autoinjectors, and Parachutes. Journal of Allergy and Clinical Immunology. 11(4). pp. 1036-1046.
  2. Allergy & Asthma Network. (n.d.). What is Epinephrine?

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