Ofloxacin ®
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Reviewed on February 10, 2026. by Dr Alexandra Cristina Cowell Writer & Clinical Content Reviewer Registered with GPhC (No. 2241935) Next review due on Feb 09, 2029.
Dr Alexandra Cristina Cowell

Last updated on February 10, 2026.

Ear drop that stops bacteria causing ear infections.

Ofloxacin is a generic antibiotic ear drop. It’s approved by the FDA to treat outer ear infections like otitis externa (also known as swimmers ear). It’s the generic version of Floxin Otic, which has been discontinued.

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Ofloxacin Ofloxacin

What is Ofloxacin?

It’s an antibiotic ear drop used to treat infections of the outer ear. It’s a type of fluoroquinolone antibiotic, which means it’s effective at treating severe infections. You’ll usually use one or two drops in the infected ear twice daily to treat otitis externa.

How does Ofloxacin work?

Ofloxacin interferes with the DNA of the bacteria causing outer ear infections. It prevents the replication and repair of the bacteria’s DNA, which stops cell division, halting the infection from spreading and eliminating it.1 This should help clear up your infection, and prevent it from coming back.

How do Ofloxacin doses work?

Ofloxacin ear drops come in one dose: a 0.3% w/w solution. That means each gram of treatment contains 3 mg of active ingredient.

What is Ofloxacin’s active ingredient?

Ofloxacin is a generic medicine that’s named after its active ingredient: ofloxacin. It’s a type of fluoroquinolone antibiotic that interferes with the DNA of bacteria causing infections to kill them off.

Treated trusted source:

  1. Graham, D.B. Tripp, J. (2023). Ofloxacin. StatPearls. Treasure Island (FL): StatPearls Publishing.
Dr Alexandra Cristina Cowell 23938
This page was medically reviewed by Dr Alexandra Cristina Cowell on February 09, 2026. Next review due on February 09, 2029.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Ofloxacin Ofloxacin

How to take Ofloxacin

You should always follow your prescribing clinician’s instructions when using Ofloxacin. Usually, you’ll use one or two drops (as instructed) twice per day (around 12 hours apart) for seven to 14 days to clear up outer ear infections. To administer the drops:

  • Wash your hands with soap and water.
  • Gently clean any discharge that’s easy to remove from the outer ear. Don’t insert anything into your ear canal, as this can make the infection worse.
  • Hold the bottle of Ofloxacin in your hand to warm the solution before applying it.
  • Lie on your side with the infected ear facing upwards, and administer the number of drops you’ve been instructed into the ear.
  • Gently pull the outer ear upwards and backwards to allow the ear drops to flow into your ear canal.
  • Stay lying on your side for at least five minutes after applying the drops.
Dr Alexandra Cristina Cowell 23938
This page was medically reviewed by Dr Alexandra Cristina Cowell on February 09, 2026. Next review due on February 09, 2029.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Ofloxacin Ofloxacin

Ofloxacin isn’t suitable for everyone, and there are some things that you need to be aware of when taking it.

Here’s all the official info on it. If anything is unclear, let our clinician know, and they can talk with you about it.

Ofloxacin Ofloxacin

Ofloxacin: FAQ

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

Are there any Ofloxacin alternatives?

Answer:
Yes. Combined Ciprofloxacin/Dexamethasone ear drops are an alternative otitis externa treatment that contain both a fluoroquinolone antibiotic (similar to Ofloxacin) and a corticosteroid. This means that it kills off the bacteria causing the infection in a similar way to Ofloxacin, and it can also help relieve inflammation, itching, and pain in the ear canal. This means it might be a good alternative if your infection is more severe or persistent.

Studies show that combined Ciprofloxacin/Dexamethasone has a higher clinical cure (90% vs 78%) and microbiologic success rate (92% vs 81.8%) when compared with Oxfloxacin. It also had fewer treatment failures (4.4% vs 14.1%) and worked in a shorter period of time (an average of four days compared to six days) than Ofloxacin.1 So it could be a good option if you’ve tried Ofloxacin and it hasn’t been effective.

Do I need a prescription for Ofloxacin?

Answer:
Yes. Ofloxacin is an antibiotic, which means a healthcare professional will need to check its the right treatment for you before you use it. Using antibiotics when they’re not needed can contribute to antibiotic resistance, which means they might not work as they should when you do need them.

How effective is Ofloxacin for otitis externa?

Answer:
Ofloxacin has proven to be a highly effective treatment for otitis externa in clinical trials. In one study of 489 individuals with otitis externa, the cure rate of Ofloxacin was 91%, with 68% of people being cured within seven days.2

How long does it take Ofloxacin to work for otitis externa?

Answer:
Ofloxacin should start to make you feel better within two or three days of starting treatment. In one study, symptom pain scores improved as soon as one day after treatment began, and the majority of people reported minimal or no pain after just four days.3

What should I do if I make a mistake when taking Ofloxacin?

Answer:
If you forget to use a dose of Ofloxacin, you should take the missed dose as soon as you remember. But if it’s almost time for your next dose, skip the one you missed and carry on as normal from your upcoming dose. Never take more Ofloxacin than you’ve been instructed to make up for missing a dose. If you do use more Ofloxacin than you should, contact your doctor right away.

Does Ofloxacin cause side effects?

Answer:
Like any treatment you use, Ofloxacin comes with some risk of side effects. Not everyone will get them, but you may experience:

  • Changes to your sense of taste

  • Earache

  • Itching

  • A burning or tingling sensation

  • Rash

  • Dizziness


If you get any of the following Ofloxacin side effects, stop using it right away and get medical attention:

  • Inflammation of the skin (rash, itching, or hives)

  • Swelling of your lips, face, mouth, tongue, or throat

  • Wheezing, shortness of breath, or difficulty breathing

  • Difficulty swallowing

  • Reddish, target-like spots or circular patches, often with blisters in the middle

Can I get Ofloxacin through private health insurance?

Answer:
If a doctor has prescribed Ofloxacin ear drops to treat an ear infection, you should be able to get them through your health insurance. But it’s always best to check your insurer’s formulary to see what treatment they cover, and to check if you need prior authorization beforehand. This is a conversation between your health insurance provider and physician to make sure Ofloxacin is a medical necessity for your condition.

Your health insurance may also only cover part of the cost of treatment – or only offer coverage if you obtain it from a specific healthcare provider. If you can’t get Ofloxacin through your health insurance, you should still be able to get it through an online pharmacy service. A healthcare professional will just need to check to make sure it’s the right treatment for you.

Treated trusted source:

  1. Roland, P.S. et al. (2004). Topical ciprofloxacin/dexamethasone otic suspension is superior to ofloxacin otic solution in the treatment of children with acute otitis media with otorrhea through tympanostomy tubes. Pediatrics. 113(1).
  2. Torum, B. et al. (2004). Efficacy of ofloxacin otic solution once daily for 7 days in the treatment of otitis externa: a multicenter, open-label, phase III trial. Clinical Therapeutics. 26(7). pp. 1046-1054.
  3. Lee, H. Kim, J. Nguyen, V. (2013). Ear Infections: Otitis Externa and Otitis Media. Primary Care: Clinics in Office Practice. 40(3). pp. 671-686.

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